General Information

  • ID:  hor001446
  • Uniprot ID:  P10419
  • Protein name:  Antho-RFamide
  • Gene name:  NA
  • Organism:  Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Anthopleura (genus), Actiniidae (family), Actiniaria (order), Hexacorallia (subclass), Anthozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QGRF
  • Length:  4
  • Propeptide:  MTTVSYVTILLTVLVQVLTSDAKATNNKRELSSGLKERSLSDDAPQFWKGRFSRSEEDPQFWKGRFSDPQFWKGRFSDPQFWKGRFSDPQFWKGRFSDPQFWKGRFSDPQFWKGRFSDPQFWKGRFSDGTKRENDPQYWKGRFSRSFEDQPDSEAQFWKGRFARTSSGEKREPQYWKGRFSRDSVPGRYGRELQGRFGRELQGRFGREAQGRFGRELQGRFGREFQGRFGREDQGRFGREDQGRFGREDQGRFGREDQGRFGREDQGRFGREDQGRFGRELQGRFGREFQGRFGREDQGRFGREDQGRFGRELQGRFGREDQGRFGREDQGRFGREDLAKEDQGRFGREDLAKEDQGRFGREDIAEADQGRFGRNAAAAAAAAAAAKKRTIDVIDIESDPKPQTRFRDGKDMQEKRKVEKKDKIEKSDDALAKTS
  • Signal peptide:  MTTVSYVTILLTVLVQVLTSDA
  • Modification:  T1 Pyrrolidone carboxylic acid;T4 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It could act as a transmitter at neuromuscular synapses
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P10419-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001446_AF2.pdbhor001446_ESM.pdb

Physical Information

Mass: 56025 Formula: C22H34N8O6
Absent amino acids: ACDEHIKLMNPSTVWY Common amino acids: FGQR
pI: 10.55 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 1
Hydrophobicity: -140 Boman Index: -1654
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 750 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2879288
  • Title:  Identification of a novel type of processing sites in the precursor for the sea anemone neuropeptide Antho-RFamide (